Can broccoli really defend us against diabetes?
Concentrated broccoli sprout extract may help type 2 diabetes patients manage their blood sugar, according to a new study. The findings could offer a much-needed alternative to address the condition, which has become a worldwide epidemic.
Type 2 diabetes afflicts more than 300 million people globally, and as many as 15% of those patients cannot take the first-line therapy metformin because of kidney damage risks.
The researchers constructed a signature for type 2 diabetes based on 50 genes, then used publicly available expression datasets to screen 3,852 compounds for drugs that potentially reverse disease. The most promising chemical -- sulforaphane, a naturally occurring compound found in cruciferous vegetables -- tamped down glucose production by liver cells growing in culture, and shifted liver gene expression away from a diseased state in diabetic rats.
When the researchers gave concentrated broccoli sprout extracts to 97 human type 2 diabetes patients in a 12-week randomized placebo-controlled trial, obese participants who entered the study with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.
For more details: - https://www.sciencedaily.com/releases/2017/06/170614141526.htm