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Brand-Hamilton
The viable cell density measurement is based on capacitance. Viable cells behave like little capacitors and their polarization and depolarization in an alternating electrical field is measured. The signal can be correlated to the bio-volume, resp. the viable cell density. Only viable cells can be polarized in the alternating electrical field so this method is insensitive to cell debris as well as to micro carriers.
Benefits:
- Specific for viable cells
- Suitable for cell culture and fermentation
- Insensitive to microcarriers and cell debris
- No more hidden events
- Optimization of feeding strategy and yield
Typical Applications:
- Eucaryotic cells
- Yeast
- High density bacteria fermentation