Sound Sensitive On Demand Pain Relief
Imagine a small hand-held device that could be directly placed on the skin and with the press of a button localized pain would vanish. Sound like something you would see in an episode of Star Trek, right? If a team of investigators, led by scientists at Boston Children’s Hospital have it their way, it will become a reality very soon, as they have just reported on a new way to noninvasively relieve pain at local sites in the body. Findings from the new study—published today in Nature Biomedical Engineering in an article entitled “Ultrasound-Triggered Local Anesthesia”—could one day improve pain management by replacing addictive opioids and short-lasting local anesthetics.
"Opioid abuse is a growing problem in healthcare," explained senior study investigator, Daniel Kohane, M.D., Ph.D., a senior associate in critical care medicine at Boston Children's and professor of anesthesiology at Harvard Medical School. "In the future, this system could potentially combat that by giving patients access to nonopioid, effective nerve-blocking drugs."
In the new study, the research team developed a novel system that uses ultrasound to trigger the release of nerve-blocking agents—injected into specific sites of the body ahead of time, when and where pain relief is needed most. Ultrasound is commercially available and widely used in various clinical and therapeutic settings, making it an attractive technology to use as a drug "trigger."
"One of the most interesting aspects of this system is that the degree of nerve block can be controlled just by adjusting the duration and intensity of the ultrasound,” noted lead study investigator Alina Rwei, a graduate researcher in Dr. Kohane's laboratory. "We envision that patients could get an injection at the hospital and then bring home a small, portable ultrasound device for triggering the nerve-blocking agent. This could allow patients to manage their pain relief at-will, noninvasively."
To create the ultrasound-triggered pain relief system, Kohane's team developed liposomes—phospholipid encased sacs that are micrometers in size—and filled them with a nerve-blocking drug. The walls of the liposomes contain small molecules called sono-sensitizers, which are sensitive to ultrasound.